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Growing older already leads you to smaller brain volume over time, but smoking lots of cigs appears to shrink your brain and prematurely age it as well, leading to higher incidence of dementia and Alzheimers

More and more studies show that OA is a whole-joint disease with a clear immune-inflammatory component, and synovitis, innate immune activation, and abnormal tissue responses all take part in cartilage damage, symptom severity, and disease progression

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2016;73:995996 [DOI] [PubMed] [Google Scholar] 4.Temple EC, Brown RF, Hine DW