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Conversely, among users who transitioned from tobacco cigarettes to e-cigarettes, evidence from three studies, including a prospective randomized controlled trial involving active tobacco smokers, indicates a significant decrease in systolic blood pressure and resting heart rate after 1 month of e-cigarette use, with or without nicotine

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Regardless of the curing method used, desirable curing endpoints include maximum production of tobacco leaf mass with minimal leaf damage caused by pests, pathogens, nutrient deficiencies, adverse weather, or other causes, but also appropriate characteristics, such as leaf color and thickness, aroma, and concentrations of nicotine and certain sugars

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