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Whats more, the US lost $185 billion was lost in productivity due to smoking-related illnesses and other health conditions, $180 billion in productivity due to smoking premature deaths, and $7 billion was lost due to productivity from secondhand smoke exposure leading to premature death

It is also a risk factor for many cancers including head and neck cancers, pancreatic cancer, oesophageal cancer and breast cancer (in post-menopausal women)

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However, epidemiological studies assessing Swedish smokeless tobacco, which exposes users to nicotine without combustion products, generally have not found an increased risk of myocardial infarction or stroke among users, but suggest that nicotine might contribute to acute cardiovascular events, especially in those with underlying coronary heart disease