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A study in Science journal, submitted by Silke Allmann and Ian T

Recent studies suggest that enhancer of zest homolog 2 (Ezh2) may increase H3K27me3 methylation at the Fbxw7 promoter, potentially repressing Fbxw7 expression, while IL-4 could reduce Fbxw7 activity to inhibit c-Jun degradation in fibrotic environments, thereby impacting pulmonary fibrosis

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doi: 10.1016/j.jacc.2017.05.043, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 77.Baldauf RW, Devlin R, Gehr P, Giannelli R, Hassett-Sipple B, Jung H, et al