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Wenger and colleagues showed that THC alters pituitary LH release by inhibiting the release of LHRH, injecting THC into the third cerebral ventricle of male rats [92]

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However, data published in 2015 suggest that large numbers of youth are initiating e-cigarette use and that as many as half of these individuals do not smoke traditional combustible cigarettes. A recent report from the Centers for Disease Control and Prevention found that rates of e-cigarette use among high schoolers jumped from 4.5% in 2013 to 13.4% in 2014 tripling in just one year

[90] Functional magnetic resonance studies have also demonstrated that the insular cortex participates in many key auditory processes such as tuning into novel auditory stimuli and allocating auditory attention