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The UK is working towards regulating and licensing ENDS as medicinal quit aids, while the US FDA provides authorisation to ENDS based on rigorous toxicology studies

There is a tendency for some people to select a low strength of nicotine when they are first using a vape kit to help them to quit

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Nicotine-induced oxidative stress also contributes to cellular damage, including in the testes, further suppressing testosterone production

In Kentucky, recent districtwide data reinforce much higher rates, with some districts indicating 75% of high school students are using e-cigarettes