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Supplementation of CR lo and CR hi cell lines with CR itself did not alter their proliferation rate (Supplemental Figure 2, AD), despite the detection of extracellularly supplied CR within the intracellular metabolite pool (Supplemental Figure 2E), indicating that CR is a cancer cellderived biomarker that accumulates with cell proliferation but does not itself induce functional effects

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The underlying belief is that pathogens are hardy enough to wait for new hosts on whatever surface they land on

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