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At the same time, it has sometimes disregarded, or even cut off, studies of its own that implicated smoking as a health hazard.[5] In February 1994, FDA Commissioner David Kessler announced evidence that tobacco manufacturers were deliberately manipulating the nicotine content in cigarettes and, as a result, the FDA was prepared to consider regulating tobacco products, a major policy shift

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While some of these compounds can exhibit an intrinsic toxicity, the heating process can also lead to the formation of new thermal decomposition compounds that may be also hazardous [2,3,4]

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