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2 The pathophysiology of Parkinsons disease Parkinsons disease, first described by James Parkinson in 1817, is a complex, age-related, progressive, and multisystem neurodegenerative condition associated with dopaminergic neuronal loss and formation of -synuclein (-Syn) protein aggregation in neurons of the substantia nigra (SN) (Ben-Shlomo et al., 2024)

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It was only through the push and pull symbiotic process of human domestication that bananas transformed into their modern shape