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Johann Michael Elasser noted the connection between pipe smoking and lip cancer in 1795, and scattered clinical observations accumulated through the nineteenth century, but the scientific case against tobacco was constructed methodically only in the mid-twentieth century

Bacon, C

The social pattern of Virginia reflected the agricultural and economic pattern of the colony

Forty-eight percent of surveyed parents were right about cigarettes

It has been hypothesized that tobacco (genus Nicotiana ) was the first domesticate in the Americas, predating, and possibly laying the foundation for, the farming of maize and other food plants (8)