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Ki-67, PCNA, p21, cyclin D1, and p53 were among the cell cycle and differentiated genes whose transcriptional and translational regulation was altered by nicotine [70]

[41] One of the primary features of the more recent generation of devices is that they contain larger batteries and are capable of heating the liquid to a higher temperature, potentially releasing more nicotine, forming additional toxicants, and creating larger clouds of particulate matter

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On the flip side, not all papers that are whitened or bleached necessarily use chlorine or other chemicals

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