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[14] [10] The discovery that hemoglobin is affected by CO emerged with an investigation by James Watt and Thomas Beddoes into the therapeutic potential of hydrocarbonate in 1793, and later confirmed by Claude Bernard between 1846 and 1857

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Additionally, the review mentions metadoxine and lithium as potentially suitable for individuals with comorbid alcohol misuse or bipolar disorder, although further large-sample, placebo-controlled studies are needed to confirm their effectiveness

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Adam P Klein, Karen Yarbrough, and John W Cole