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By 2013, Tips was associated with an estimated 220,000 sustained (6-month) quits among American adult cigarette smokers, and this number grew to an estimated 522,000 and 1,005,419 by 2015 and 2018, respectively 54

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There are increasing reports of e-liquids containing recreational drugs such as synthetic cannabinoid receptor agonists, crack cocaine, LSD, and methamphetamine

Third, demographic or baseline characteristics may influence perceptions of specific descriptors, indicating that the meaning of descriptors may change depending on the individual

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