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Since the TPD took force in 2016, EU smoking prevalence has fallen 3 percent

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Conclusions The present study highlights the observably and measurably detrimental impacts of heavy smoking on systemic health, demonstrating substantial elevations in oxidative stress markers, inflammatory biomarkers, and vascular dysfunction indicators

The study protocol was approved by the Ethics Committee of Mario Negri Institute (Ethics Committee of Fondazione IRCCS Istituto Neurologico Carlo Besta, ID: 15, date: 17 May 2023)