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However, the concentrated nicotine can cause severe gastrointestinal upset, heartburn, and nausea

Smoking impacts the majority of your organs

Both the tissue-resident macrophages and peripheral nerve macrophages secrete a variety of mediators, such as high mobility group box 1, interleukin 1 (IL-1), and IL-6, that regulate the excitability of primary afferents and neurons and contribute to the pathogenesis of inflammatory and neuropathic pain (Sekiguchi et al., 2018)

We present the findings on smoking and type 2 diabetes as an example of a 3-star risk association

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