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After years of research, it is only recently that the FDA (Food and Drug Administration) announced that there are not major safety concerns when using several Nicotine Replacement and Over-the-counter Therapies at once

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Ethical approval and informed consent All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

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Higher doses overwhelm nerve function, leading to paralysis and possibly death