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In postmenopausal women, bone mineral density was significantly lower in smokers than in non-smokers in a human clinical study

However, ejuice and vaping is concretely shown to be safer than smoking, even though it does have its own problems

10.1038/clpt.1993.27

4 million the number of people who die in Asia annually from a smoking-related disease In 2009, tobacco was in the top three risk factors for nine of the countries covered by this briefing, while in four countries China, Japan, Singapore and Thailand, it was ranked number one