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Other toxic substances, like certain volatile organic compounds (VOCs) and even some heavy metals, can also be present in e-cigarette vapours (from various sources, including the e-liquid itself, the e-cigarette device, and even through secondary reactions), and in industrial environments

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A review of the literature on how methylation affects initiation, dependency, and cessation by the American Council on Science and Health concluded: Overall, the evidence summarized in this section does not suggest that mentholated cigarettes are associated with any independent reduction in age of starting to smoke (starter product for youth), increase in cigarette consumption or dependency (greater addiction potential)