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83 In addition, HMGB1 is a known ligand for TLR2 and TLR4

This interruption causes irregular gastric emptying and intestinal motility, exacerbating indigestion and heartburn

Congenital syphilis can cause: Miscarriage (losing the baby during pregnancy) Stillbirth (a baby who dies before birth) Prematurity (a baby born early) Low birth weight Death shortly after birth Babies born with CS can have: Abnormal bones Severe anemia (low red blood cell count) Large liver and spleen Jaundice (yellowing of the skin or eyes) Brain and nerve problems, like blindness or deafness Infection in the spinal fluid Skin rashes Early symptoms, like a sore or rash, will eventually go away on their own, even without treatment