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Demonstration that GABA reversal potential in DA neurons is unaffected by nicotine in Figure 1, or that non-DA neurons recorded in VTA show diazepam-induced increase in firing after nicotine would strengthen the conclusions We agree it is important to show the diazepam-induced increase in non-DA neuron firing following nicotine exposure

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One-year data showed smokers who switched exclusively to glo, our Tobacco Heating Product, achieved significant and sustained improvements in several indicators of potential harm compared to those who continued to smoke