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Nrf2 is inactive in the cytosol, where it is bound to Keap1, and in the presence of oxidative stress or electrophiles, it separates from Keap1 and translocates into the cell nucleus [20]

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IARC, Lyon, France Jalas J, Hecht SS, Murphy SE (2005) Chem Res Toxicol 18:95110 Johnson L, Mercer K, Greenbaum D et al (2001) Nature 410:11111116 Kim MY, Cho MH (2009) Toxicol Ind Health 25:189195 Kim V, Rogers TJ, Criner GJ (2007) Semin Thorac Cardiovasc Surg 19:135141 Lee JM, Yanagawa J, Peebles KA et al (2008) Crit Rev Oncol Hematol 66:208217 Le Marchand L, Derby KS, Murphy SE et al (2008) Cancer Res 68:91379140 Lijinsky W (1992) Chemistry and Biology of N -Nitroso Compounds