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Erythrocytes affect hemostasis and thrombosis by altering blood viscosity, blood flow dynamics, secreting RBC-derived microvesicles, interactions with platelets or endothelial cells, fibrinogen-induced RBC aggregation, activation of blood coagulation factors, direct modulation of thrombin and fibrin formation, or formation of polyhedral-like erythrocytes in thrombi [47,48,49]

The substance contained in the electronic cigarette may contain varying amounts of nicotine or other chemicals with the purpose of providing different flavours

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Additional blood samples were drawn at 5 minutes (taking 10 puffs) and every 15 minutes during 1 hour of ad lib EC use (Figure 1)