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Some companies have seen FDA applications for new nicotine products languish for years or, like Juul, faced rejections they have challenged in court

The researchers did this to study the true difference between the drugs and prevent a negative bias against bupropion SR

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In the US, youth cigarette smoking, at 5.8% in 2019, declined by 63.3% from 2011 to 2019 (compared to only a 17.4% decline from 2003-2011 when e-cigarettes were not widely used), suggesting that vaping is an exit ramp than a gateway to smoking