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Tobacco Substance Use CDC How many adolescents use tobacco? National Institute on Drug Abuse (NIDA) Cigarette smoke contains thousands of chemicals, many of which are toxic and harmful to the human body. Here's a detailed breakdown of some of the most dangerous constituents and their effects: 1. More than one third of U.S. teens have used at least one substance by age 16, according to a new study led by researchers at the University of California San Diego that found Fact Sheet: Arguments against "Gateway to Smoking Addiction" Claims

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