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31.Mitchell A, Walker L

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NO is produced by the endothelial nitric oxide synthase (eNOS) and diffuses to the smooth muscle cells where it binds to the soluble guanylyl cyclase (sGC) that activates the cGMP-dependent protein kinase [63], leading to a reduction of intracellular calcium levels and thus to relaxation [53]

They feel comfortable saying basically anything to each other, and that's important to keep note of as they both have a deep fondness for each other

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