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It has also been shown that cbNPs accumulate in antigen-presenting dendritic cells derived from emphysematous lung tissue of smokers [73] and that cigarette smoke triggers the NLRP3 inflammasome [63], which is again consistent with the observation that IL-1 levels are elevated in smokers lungs [19]

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The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review