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After reviewing a number of cases, the Appellate Body stated, "the 'treatment no less favourable' standard of Article III:4 of the GATT 1994 prohibits WTO members from modifying the conditions of competition in the marketplace to the detriment of the group of imported products vis--vis the group of domestic like products." 75 The Appellate Body elaborated on how its standard should be applied when de facto discrimination is alleged: Accordingly, where the technical regulation at issue does not de jure discriminate against imports, the existence of a detrimental impact on competitive opportunities for the group of imported vis--vis the group of domestic like products is not dispositive of less favourable treatment under Article 2.1

Although research activity occurred across 53 foreign (non-US) countries, 97.8% (91) of the grants were awarded to institutions in HICs (primarily the US, Canada, and the UK), with only three grants awarded directly to LMIC institutions in two countries (India and Mexico)