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Signs and Symptoms of Suboxone Misuse If you suspect that a loved one is misusing Suboxone, you can look for behavioral signs of opiate addiction, such as: Sudden mood swings Noticeable signs of euphoria Isolation Secrecy Legal issues Inability to fulfill commitments Issues with work, school, family or friends Sudden financial problems and the need for quick cash Changes in routines or habits Using more medication than prescribed Visiting multiple doctors to obtain more prescriptions for opioids An inability to stop using the drug A Suboxone high may produce similar symptoms as any opiate