The exact causative variant(s) in their genome has/have not yet been defined, but that is an active area of investigation
Thats why healthcare professionals typically advise against using hormonal contraception containing estrogen, particularly if you use tobacco products or are over 35 years old
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[DOI] [PubMed] [Google Scholar] [168].Russo MT, Blasi MF, Chiera F, Fortini P, Degan P, Macpherson P, Furuichi M, Nakabeppu Y, Karran P, Aquilina G, Bignami M, The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells, Mol Cell Biol, 24 (2004) 465474
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