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Smoking affects the heart long before symptoms appear. Each cigarette delivers chemicals that enter the bloodstream within seconds, reaching the heart and blood vessels almost immediately. These substances damage the inner lining Frontiers A modern day perspective on smoking in peripheral artery disease does smoking cigarettes clog your arteries Cardiovascular Disease & Smoking EX Smoking cessation for 30 years confers reduced PAD risk similar to never smokers Requiring ugly images of smoking's harm on cigarettes won't breach First Amendment, court says The Hill

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