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Biological Research for Nursing, 27 (1), 168185

Because the collection process is directly observed, oral fluid testing greatly reduces the opportunity for specimen substitution, dilution, or adulteration while simplifying collection in workplaces, healthcare facilities, schools, correctional institutions, and field testing environments

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The source of ROS varies between the gas or tar phase of cigarette smoke, monocytes, macrophages, neutrophils, and endogenous sources from xanthine oxidase, endothelial nitric oxide synthase (eNOS), and the mitochondrial electron transport chain ( 15 , 16 )