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Examples of increased risk factors for cannabis induced psychosis or schizophrenia include: heavy long-term cannabis use, a history of child abuse, a family history of psychotic disorders, or certain genetic predispositions: certain variants in the genes COMT and AKT1 are linked to a predisposition to psychotic disorders (10) PGx and the Future of Personalized Medicine Using PGx to guide cannabis usage for patients could provide a potential way of reducing the risk of negative symptoms