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Although the directionality of these alterations may depend on the cell type, disease status or time or dose of exposure, this collective body of evidence demonstrates that the molecular regulation of mitochondrial biogenesis is disturbed in COPD patients and is impacted by smoking in epithelial cells of both the bronchial and alveolar compartment

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Luo et al

What to expect The session opens with a soft, lightly toasted tobacco note and quickly settles into a steady, medium-bodied character that holds across the full draw count