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Elevated estradiol levels amidst normal total testosterone suggest that smoking may interfere with the hormonal balance required for optimal male reproduction

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53 Hajek et al 54 randomized 886 smokers to e-cigarette or nicotine replacement products of their choice

Reducing dependency on nicotine can be difficult so the process of weaning off via replacements such as patches, gum or vapes is seen as a positive approach to eventually quitting the need to absorb the addictive chemical