A recent study using longitudinal within-subjects observational method showed that switching from c-cigarettes to e-cigarettes substantially reduced several carcinogens and toxicants such as the metabolites of 1,3-butadiene, benzene and acrylonitrile, while nicotine exposure remains unchanged 22
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"The distinct patterns of these heart disease risk biomarkers in blood serum of frequent users of combustible cigarettes and e-cigarette products indicate that, despite the similar physiological effects, e-cigarette use and smoking trigger fundamentally different molecular responses
Cent Nerv Syst Agents Med Chem 14:1022 Turgano L, Martnez-Rodrguez R, Alvarez MI, Gragera RR, Gmez de Segura A, De Miguel E, Toledano A (2001) Histochemical study of acute and chronic intraperitoneal nicotine effects on several glycolytic and Krebs cycle dehydrogenase activities in the frontoparietal cortex and subcortical nuclei of the rat brain
