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Moreover, the PSD is likely to change as the aerosol travel down the respiratory tree, due to hygroscopic growth and fusion of droplets 39

Hence, if e-cigarette use impacts ever smoking, it may have downstream effects on the prevalence of health-damaging courses of smoking

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In contrast relatively higher rates of smoking have persisted in patients with inflammatory bowel disease (IBD), in particular Crohns disease (CD), with prevalence rates of those who have ever smoked ranging between 8.7% and 64% in large cohorts [3]