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In that peak year, more than 5 million US middle- and high-school students were current e-cigarette users (with nearly 1 million vaping daily), a dramatic surge that reversed prior declines in overall youth tobacco use (18)

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In addition, the proposed rule would require a voluntary withdrawal request of an SE report to state whether a withdrawal is due to a safety concern related to the tobacco product

From a general summing up of the opinions which have been quoted the question might finally be asked, Is tobacco on the whole harmful or beneficial to its users? The answer seems to be this: Tobacco to the extent used on the average has some slight injurious effects and some slight beneficial effects on the physical system