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However, we believe that both approaches serve to reduce the harm caused by smoking, though for very different reasons. According to him, it has been hypothesized for many years that a high nicotine tobacco when combined with a low tar yield cigarette design will result in smokers inhaling far less smoke and far less tar, both considered to be the primary disease-causing agents of cigarettes

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The overall level of concern on methodological soundness rating was not an inclusion criterion

Almost half of the study participants (n=207