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Therefore, although outside of the scope of the present work, additional research on product shelf life and stability, as well as consumer perception and behavioral studies, toxicity studies, and human biomarker levels, will help to predict health outcomes that may be expected when consumers use reduced-exposure products

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Although the long-term effects are still unknown, nicotine exposure during adolescence may have adverse consequences for brain development and could lead to dependence 21,101-103

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