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The relative deactivations observed in orbitofrontal cortex (generally recognised as an area that responds to olfactory stimuli 36 ) may therefore be a result of the less powerful olfactory properties of ENDS, and this area (plus other olfactory areas such as the piriform cortex) may respond more strongly to tobacco cigarette smoking

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Subjective and behavioural effects of nicotine in humans: some sources of individual variation

The knee-jerk reaction to this question is, quite simply, yes

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