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There are some limitations to this study that should be highlighted

PATERNAL prepubertal exposure to passive smoke is associated with impaired lung function trajectories in their children, persisting from childhood into middle age and raising the risk of chronic obstructive pulmonary disease (COPD)

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Furthermore, increased expression of BAG2 shifts the effects of nicotine toward a reduction in levels of p-tau protein, possibly as a consequence of BAG2 inhibition of ERK1/2 via association with Hsp90, which is required for ERK1/2 activity, and/or via BAG2-mediated degradation of p-tau as a consequence of BAG2 phosphorylation by p38/MAPKAPK2 [206]