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Dose, tolerance, digestion, food, and product type all matter

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study

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And theres a very interesting line of research right now into the actual processing itself and whether foods are less satiating, for example, and easier to overeat simply because theyve used these chemical additives to manipulate the texture of the food to make it a little less satiating