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J Biol Chem 291:47634778 Tagawa Y, Hiramatsu N, Kato H, Sakoh T, Nakajima S, Hayakawa K, Saito Y, Johno H, Takahashi S, Gu L, Yao J, Kitamura M (2011) Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2alpha pathway

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Harm Reduction Approaches For those choosing to use tobacco despite known risks, certain practices may reduce exposure levels: Using less tobacco per cigarette reduces intake per smoke Filtering reduces tar and particulate matter Organic, additive-free tobacco eliminates some chemical exposures Spacing cigarettes further apart decreases daily consumption None of these approaches make tobacco safethey merely adjust exposure levels