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Traditional tobacco has been used by American Indian nations for centuries as a medicine with cultural and spiritual importance

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ACS, acute cigarette smoking AMs, alveolar macrophages BALF, bronchoalveolar lavage fluid CO, carbon monoxide COPD, chronic obstructive pulmonary disease CS, cigarette smoke CSE, cigarette smoke extract EIC, elastase inhibitory capacity GSH, reduced glutathione GSSG, oxidised glutathione HO-1, heme oxygenase-1 IFN-, interferon- IL, interleukin NE, neutrophil elastase NO, nitric oxide PMNs, polymorphonuclear cells TBARS, thiobarbituric acid reactive substances TEAC, trolox equivalent antioxidant capacity TNF-, tumour necrosis factor chronic obstructive pulmonary disease smoking inflammation oxidative stress Statistics from Altmetric.com ACS, acute cigarette smoking AMs, alveolar macrophages BALF, bronchoalveolar lavage fluid CO, carbon monoxide COPD, chronic obstructive pulmonary disease CS, cigarette smoke CSE, cigarette smoke extract EIC, elastase inhibitory capacity GSH, reduced glutathione GSSG, oxidised glutathione HO-1, heme oxygenase-1 IFN-, interferon- IL, interleukin NE, neutrophil elastase NO, nitric oxide PMNs, polymorphonuclear cells TBARS, thiobarbituric acid reactive substances TEAC, trolox equivalent antioxidant capacity TNF-, tumour necrosis factor Footnotes This review was supported by a grant from Astra Zeneca.