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It has been found that a high dose of TNF can destroy the tumor vasculature and cut-off the supplement of O2 and nutrition for tumor growth to exert necrotic effects in tumors (92)

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PI-3K = phosphatidylinositol 3-kinase

Smoke is known to induce airway inflammation via IL-6 and IL-8 production and recruit inflammatory cells including neutrophils, however the mechanism causing the release of these cytokines has not been well described 32

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