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Briefly, human in vitro systems do not reflect all aspects of cellular interaction and tissue organization, in vivo animal models do not necessarily reflect human biology in its finer details, and human clinical studies are hampered by time and cost constraints as well as accessibility to key biological samples (that are accessible in animal studies)

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Changes in mortality from smoking in two American cancer society prospective studies since 1959

And in May, BBC News unearthed unnamed vapes confiscated from school pupils containing high levels of lead, nickel and chromium, with investigations revealing that children using them could be inhaling more than twice the daily safe amount of lead (which can affect the central nervous system and brain development), and nine times the safe amount of nickel (which can cause health problems including rhinitis, sinusitis, anosmia and more)