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Thats literally the level of debate we have on this matter at the moment regarding lit tobacco and trying to reduce the scourge it has on the health of the world, and it staggers me that This Is Even A Thing

We think that while it is clear that different endpoints may yield quite different results, the human MOE for cannabis based on the endpoint psychotropic effects can be seen as general validation of the MOE concept, because the resulting values below 1 are expected as the psychotropic effect is the desired endpoint (and hence the psychotropic threshold dose is exceeded by drug users)

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The uncertainty of the prevalence estimates was assessed using simulation methods [25]