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Twenty-three studies 18,22,25-29,31,33,35-37,39,40,42-48,50,52 (59%) evaluated the effects of acute exposure, nine studies 15,17,26,29,33,34,41,49,51 (23%) short-to-medium term exposure, and one study 20 (3%) examined effects of long-term exposure

Due to the Brattleboro homozygous vasopressin-deficient rat's reduced sensitivity to several ulcerogenic stimuli compared to the rat with normal vasopressin secretion, endogenous vasopressin has been shown to operate as an aggressive factor towards the gastroduodenal mucosa [21]

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Imperial Tobacco Limited case in Scotland, arguing that the plaintiffs could not reasonably prove that the plaintiffs smoking caused lung cancer