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Furthermore, clinical trials have shown that standard NRT doses are inadequate for rapid metabolizers of nicotine (i.e., those who inactivate nicotine to cotinine and then to 3-hydroxycotinine [3-HC] more quickly than others due to genetic variation affecting the activity of the hepatic enzyme CYP2A6) [20, 25]

This is why smokers reach for a cigarette not just for pleasure, but to feel normal

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The ETUAS was calculated as the mean score of these four items, with higher scores indicating favorable attitude and endorsement of tobacco use

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