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This year was very complicated because of the weather, he said

BAT reported 1.01 billion pounds ($1.8 billion) in profits in 1998 on its worldwide cigarette business, according to its latest available annual report

50% American Flue Cured 50% Canadian Flue Cured *FULL/ROBUST* 40% Canadian Flue Cured 30% American Flue Cured 30% Burley *ROBUST* 80% Canadian Flue Cured 20% American Flue Cured *MEDIUM/FULL* 50% Organic Canadian Virginia Flue Cured 50% Organic American Virginia Flue Cured *FULL*

Combining this procedure with random mutagenesis, we obtained a TEV protease variant with increased in vivo processivity of recognition sequences containing large, branched and positively charged amino acids at the P1' position